gender dysphoria When someone feels uncomfortable or unhappy with his or her physical sex, the result is gender dysphoria. It often manifests in children as young as two to four years of age as a desire to be, or a belief that he or she is of the opposite sex. A boy may engage in girlish behavior, playing with dolls or wanting to wear dresses. A girl may want to wear boys clothing, want to engage in rough play, and often is considered a tomboy. Sometimes the feeling of having the wrong physic